Dhea supplementation and cognition in postmenopausal women.

Long-term low-dose dehydroepiandrosterone oral supplementation in early and late postmenopausal women modulates endocrine parameters and synthesis of neuroactive steroids.

OBJECTIVE To evaluate the effects of a low-dose DHEA supplementation on hormonal parameters in early and late postmenopausal women. DESIGN Prospective case study. SETTING Postmenopausal women in a clinical research environment. PATIENT(S) Twenty postmenopausal women were divided in two groups according to age (50-55 and 60-65 years). INTERVENTION(S) All patients underwent hormonal evalu...

DHEA therapy for women: effect on sexual function and wellbeing.

DHEA is increasingly available commercially as a supplement aimed at improving libido and wellbeing in postmenopausal women. However there is scant evidence to support the use of DHEA for this purpose, and safety data for DHEA therapy are lacking. Dehydroepiandrosterone (DHEA) and its sulphate DHEAS are the most abundant circulating sex steroid hormones in women, providing a large precursor res...

Metabolism of DHEA in postmenopausal women following percutaneous administration.

The marked decline in serum dehydroepiandrosterone (DHEA) with age is believed to play a role in health problems associated with aging, these health issues being potentially preventable or reversible by the exogenous administration of DHEA. In the present study, liquid chromatography/mass spectrometry/mass spectrometry (LC/MS/MS) and gas chromatrography/mass spectrometry (GC/MS) were used to me...

Oral dehydroepiandrosterone might prevent frequent tears in atrophic skin: A case report

INTRODUCTION Large superficial tears frequently develop during minor trauma to the fragile skin of older men and women. These tears are more common in chronically ill or malnourished patients, can develop during attempted assisted transfer of weak patients, and were recently reported to have been treated annually in 1.5 3 10 MediCare patients during their care in an acute or long-term medical c...

Investigation of the Changes in Serum Intercellular and Vascular Adhesion Molecules (ICAM-1 and VCAM-1) and Nitric Oxide Levels in Response to Exercise Training and L-arginine Supplementation in Postmenopausal Hypertensive Women